Identification of an Apa I polymorphism within the human adenosine deaminase (ADA) gene
نویسندگان
چکیده
منابع مشابه
P-115: The Role of G22A Adenosine Deaminase 1 Gene Polymorphism and The Activities of ADA Isoenzymes in Fertile and Infertile Men
Background Some studies have revealed enzymatic and non-enzymatic roles of adenosine deaminase (ADA) in male reproductive system such as regulating adenylate cyclase activity by decreasing adenosine concentration, helping to interaction between prostasomes and spermatozoa. MaterialsAndMethods frequency distribution of ADA1 G22A alleles and genotypes in 200 fertile and 200 infertile men. The pol...
متن کاملEvaluation of the adenosine deaminase (ADA) G22A gene polymorphism with recurrent spontaneous abortion among Egyptian patients
Introduction Adenosine and deoxyadenosine metabolism is influenced by adenosine deaminase (ADA) enzyme. ADA increases in different diseases and is considered as one of the markers for cell-mediated immunity. Pregnancy is associated with depressed cell-mediated immunity. The level of ADA expression, which seems to play a key role in maintaining pregnancy, is influenced by adenosine deaminase G22...
متن کاملEvaluation of Adenosine Deaminase (Ada) in Tuberculous Pleurisy
Tuberculosis is a global health problem whose morbidity and mortality is increasing, as one-third of the world population is estimated to be infected with Mycobacterium tuberculosis and eight million new active cases occur annually commonest being pulmonary tuberculosis and is often associated with effusion. Delay in diagnosis and treatment results in poor prognosis. Adenosine deaminase estimat...
متن کاملG22A Polymorphism of Adenosine Deaminase and its Association with Biochemical Characteristics of Gestational Diabetes Mellitus in an Iranian Population
Adenosine deaminase (ADA) is an important regulator of insulin action. The single nucleotide polymorphism (SNP) G22A in the ADA gene decreases enzymatic activity of ADA. The aim of this study was to investigate the relationship between the SNP G22A and blood glycemic control, insulin resistance, and obesity of gestational diabetes mellitus (GDM) patients in an Iranian population. SNP G22A was d...
متن کاملAdenosine deaminase (ADA) isoenzymes ADA1 and ADA2 in biological fluids.
We read with great interest the editorial by GAKIS [1] about the extreme importance of the adenosine deaminase (ADA) isoenzymes ADA1 and ADA2 on the homeostasis of 2' deoxyadenosine and adenosine, especially when monocytes and macrophages are infected by intracellular microorganisms. Serum ADA activity is increased in various conditions such as liver disease, tuberculosis, typhoid, infective mo...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1989
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/17.9.3626